UCLA Integrated Substance Abuse Programs, Los Angeles, CA 90025, USA.
J Subst Abuse Treat. 2012 Oct;43(3):285-90. doi: 10.1016/j.jsat.2011.12.009. Epub 2012 Feb 1.
Prescription opioid (PO)-dependent treatment presentations are becoming increasingly common; however, most research on the treatment of opioid-dependent populations has been conducted in heroin users. The aim of this secondary data analysis was to compare the buprenorphine induction experience of 167 heroin and 61 PO users. Results demonstrate that although the groups differed on some baseline characteristics, many of the key induction experience variables were comparable between the groups. Heroin users were found to have significantly higher preinduction Clinical Opiate Withdrawal Scale (COWS) scores (p = .014) and postinduction COWS score (p = .008) compared with the PO users. No differences between groups were found for self-reported craving and withdrawal scores, mean buprenorphine dose on Day 1, or retention at the end of the first week. The findings of this study suggest that existing buprenorphine induction practices developed for heroin users appear to be equally effective with PO users.
处方阿片类药物（PO）依赖治疗的病例越来越常见；然而，大多数针对阿片类药物依赖人群的治疗研究都是在海洛因使用者中进行的。本二次数据分析的目的是比较 167 名海洛因和 61 名 PO 使用者的丁丙诺啡诱导经验。结果表明，尽管两组在一些基线特征上存在差异，但两组之间的许多关键诱导经验变量具有可比性。与 PO 使用者相比，海洛因使用者在诱导前临床阿片类戒断量表（COWS）评分（p =.014）和诱导后 COWS 评分（p =.008）方面显著更高。两组在自我报告的渴望和戒断评分、第 1 天的丁丙诺啡平均剂量或第 1 周结束时的保留率方面均无差异。这项研究的结果表明，针对海洛因使用者开发的现有丁丙诺啡诱导实践似乎对 PO 使用者同样有效。
