开展处方阿片类药物依赖的临床研究：确定研究人群。
Conducting clinical research with prescription opioid dependence: defining the population.
机构信息
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA.
出版信息
Am J Addict. 2010 Mar-Apr;19(2):141-6. doi: 10.1111/j.1521-0391.2009.00017.x.
Abstract
Most treatment studies of opioid-dependent populations have focused predominantly on heroin users, despite a recent increase in those dependent upon prescription opioids. A key methodological challenge involved in studying the latter group involves defining the population. Specifically, researchers must decide whether to include (1) concurrent heroin users and (2) individuals with pain. The multi-site Prescription Opioid Addiction Treatment Study is examining treatments for this population. This paper describes various inclusion criteria considered by the study team related to heroin use and pain. The goal was to recruit a distinct but generalizable population of individuals dependent upon prescription opioids. (Am J Addict 2010;00:1-6).
摘要
大多数针对阿片类药物依赖人群的治疗研究主要集中在海洛因使用者身上，尽管最近依赖处方类阿片药物的人数有所增加。在研究后者时，一个关键的方法学挑战涉及到定义人群。具体来说，研究人员必须决定是否包括（1）同时使用海洛因的人和（2）有疼痛的人。多地点处方类阿片成瘾治疗研究正在研究针对这一人群的治疗方法。本文描述了研究小组考虑到海洛因使用和疼痛而制定的各种纳入标准。研究的目的是招募一个独特但具有普遍性的依赖处方类阿片药物的人群。（美国药物滥用杂志 2010；00:1-6）。
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