Center for Biomarkers and Emerging Technologies, Program in Women's Oncology, Department of Obstetrics and Gynecology, Women and Infants Hospital, Brown University, Providence, RI 02905, USA.
Am J Obstet Gynecol. 2012 Apr;206(4):349.e1-7. doi: 10.1016/j.ajog.2011.12.028. Epub 2011 Dec 30.
The purpose of this study was to establish normal ranges for human epididymis protein 4 (HE4) serum levels in healthy women.
HE4 levels were measured in healthy women and analyzed by age, menopausal status, and pregnancy status. Upper 95th percentiles were determined for normal ranges.
Serum samples from 1101 healthy women and 67 pregnant women were analyzed. Above the age of 40 years significant elevations in HE4 concentrations emerged with advancing age. The upper 95th percentile for HE4 levels was 89 pmol/L for premenopausal women, 128 pmol/L for postmenopausal women, and 115 pmol/L for all women. There was a significant difference in the median serum HE4 levels in premenopausal women (46.6 pmol/L) compared with postmenopausal women (57.6 pmol/L; P < .001). In pregnant women, median HE4 concentrations were significantly lower than their premenopausal counterparts (P < .001).
HE4 serum concentrations vary significantly on the basis of age. These variations must be considered when the upper limit of normal for HE4 is determined.
本研究旨在建立健康女性人附睾蛋白 4（HE4）血清水平的正常范围。
测量健康女性的 HE4 水平，并按年龄、绝经状态和妊娠状态进行分析。确定正常范围的 95%上限。
分析了 1101 名健康女性和 67 名孕妇的血清样本。年龄超过 40 岁时，HE4 浓度随着年龄的增长而显著升高。绝经前女性的 HE4 水平 95%上限为 89pmol/L，绝经后女性为 128pmol/L，所有女性为 115pmol/L。绝经前女性（46.6pmol/L）与绝经后女性（57.6pmol/L；P<0.001）的中位血清 HE4 水平存在显著差异。孕妇的中位 HE4 浓度明显低于绝经前女性（P<0.001）。
HE4 血清浓度随年龄显著变化。在确定 HE4 的正常上限时，必须考虑这些变化。
