Department of Biochemistry, University of Hong Kong, Hong Kong, China.
J Hum Genet. 2012 Apr;57(4):244-6. doi: 10.1038/jhg.2012.11. Epub 2012 Feb 2.
A study was conducted to validate the most significant single nucleotide polymorphism (SNP) from a genome-wide association study of Japanese adolescent idiopathic scoliosis (AIS) patients in an independent southern Chinese population. In total, 300 AIS patients fulfilled the clinical criteria and 788 controls with MRI scans of the spine were included in the replication study. We employed case-control analysis to study the association of SNP rs11190870 near LBX1 (ladybird homeobox 1) with AIS in a southern Chinese population. The results suggest that SNP rs11190870 is significantly associated with AIS (P=9.1 × 10(-10); odds ratio=1.85; 95% confidence interval=1.52-2.25). The results of this study confirm that SNP rs11190870 is associated with AIS.
一项研究旨在验证日本青少年特发性脊柱侧凸（AIS）患者全基因组关联研究中最显著的单核苷酸多态性（SNP），该研究在一个独立的中国南方人群中进行。共有 300 名 AIS 患者符合临床标准，788 名接受脊柱 MRI 扫描的对照者纳入了该研究的复制研究。我们采用病例对照分析研究了中国南方人群中位于 LBX1（瓢虫同源盒 1）附近的 SNP rs11190870 与 AIS 的相关性。结果表明，SNP rs11190870 与 AIS 显著相关（P=9.1×10(-10)；比值比=1.85；95%置信区间=1.52-2.25）。这项研究的结果证实了 SNP rs11190870 与 AIS 相关。
