Department of Orthopaedics, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, PR China; Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, PR China.
Int J Surg. 2018 Jun;54(Pt A):193-200. doi: 10.1016/j.ijsu.2018.01.051. Epub 2018 Mar 10.
Adolescent idiopathic scoliosis (AIS) is the most common structural deformity of the spine. Genetics constitute largely to AIS, and the rs11190870 polymorphism has the potential for use in public health and clinical settings as a predictor of AIS risk. The aim of the present meta-analysis was to provide exhaustive evidence to evaluate the association of rs11190870 with the susceptibility and severity of adolescent idiopathic scoliosis (AIS) in multiple ethnic groups and different genders.
The professional databases, including PubMed, Embase, Social Sciences Citation Index, CINAHL, and International Bibliography of the Social Sciences, were searched from 1966 to October 2015. No language restriction was applied. Reference lists of all the selected articles were hand-searched for any additional studies. Three authors independently extracted data from all eligible studies. The data were analyzed by meta-analysis using fixed-effects or random-effects models with mean differences and risk ratios for continuous and dichotomous variables, respectively.
Eight studies were included, and the pooled analysis suggested that the T genotype of SNP rs11190870 leads to a higher risk of AIS in multiple ethnic groups regardless of gender (Total:OR, 1.66, 95% CI 1.53, 1.79; I = 37.3%, P = 0.000, Female: OR, 1.62, 95% CI 1.50, 1.73; I = 26.7%, P = 0.000, Male: OR, 1.79, 95% CI 1.38, 2.20; I2 = 0.00%, P = 0.000). Additionally, the TT and TC genotype had a larger Cobb angle than those with the CC genotype in the overall and female Asian populations.
A significant association of rs11190870 with AIS was observed in multiple ethnic groups regardless of gender. Additionally, a significant association was found between rs11190870 and curve severity in the overall and female Asian populations. Due to the limited data and clinical heterogeneity, further studies with large sample sizes are required.
青少年特发性脊柱侧凸（AIS）是脊柱最常见的结构性畸形。遗传因素在很大程度上构成了 AIS，rs11190870 多态性有可能作为 AIS 风险的预测因子，用于公共卫生和临床环境。本荟萃分析的目的是提供详尽的证据，以评估 rs11190870 与多种族裔和不同性别的青少年特发性脊柱侧凸（AIS）易感性和严重程度的相关性。
专业数据库，包括 PubMed、Embase、社会科学引文索引、CINAHL 和国际社会科学文献目录，从 1966 年到 2015 年 10 月进行了搜索。未应用语言限制。所有选定文章的参考文献均进行了手工检索，以获取任何其他研究。三位作者独立地从所有合格的研究中提取数据。使用固定效应或随机效应模型，分别使用均数差值和风险比分析数据，用于连续和二分类变量。
共纳入 8 项研究，汇总分析表明，SNP rs11190870 的 T 基因型导致多种族裔的 AIS 风险增加，无论性别如何（总体：OR，1.66，95%CI 1.53，1.79；I = 37.3%，P = 0.000，女性：OR，1.62，95%CI 1.50，1.73；I = 26.7%，P = 0.000，男性：OR，1.79，95%CI 1.38，2.20；I2 = 0.00%，P = 0.000）。此外，在总体和女性亚洲人群中，TT 和 TC 基因型的 Cobb 角大于 CC 基因型。
在多种族裔中，无论性别如何，rs11190870 与 AIS 均显著相关。此外，rs11190870 与总体和女性亚洲人群的曲线严重程度显著相关。由于数据有限和临床异质性，需要进一步进行大样本量的研究。
