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本文引用的文献

1
Rv3615c is a highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection.Rv3615c 是一种高度免疫显性 RD1（差异区 1）依赖性分泌抗原，针对结核分枝杆菌感染具有特异性。
Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5730-5. doi: 10.1073/pnas.1015153108. Epub 2011 Mar 22.
2
Screening of predicted secreted antigens from Mycobacterium bovis identifies potential novel differential diagnostic reagents.牛分枝杆菌预测分泌抗原的筛选鉴定出潜在的新型鉴别诊断试剂。
Clin Vaccine Immunol. 2010 Sep;17(9):1344-8. doi: 10.1128/CVI.00261-10. Epub 2010 Jul 28.
3
Development of a skin test for bovine tuberculosis for differentiating infected from vaccinated animals.牛结核病感染与免疫动物鉴别用皮试的研制。
J Clin Microbiol. 2010 Sep;48(9):3176-81. doi: 10.1128/JCM.00420-10. Epub 2010 Jun 30.
4
Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis.病毒加强疫苗可增强卡介苗诱导的针对牛结核病的保护作用。
Infect Immun. 2009 Aug;77(8):3364-73. doi: 10.1128/IAI.00287-09. Epub 2009 Jun 1.
5
Effect of paratuberculosis on the diagnosis of bovine tuberculosis in a cattle herd with a mixed infection using interferon-gamma detection assay.副结核病对使用γ-干扰素检测法诊断混合感染牛群中牛结核病的影响。
Vet Microbiol. 2009 Mar 30;135(3-4):389-93. doi: 10.1016/j.vetmic.2008.09.060. Epub 2008 Sep 21.
6
Screening of highly expressed mycobacterial genes identifies Rv3615c as a useful differential diagnostic antigen for the Mycobacterium tuberculosis complex.对高表达分枝杆菌基因的筛选确定Rv3615c是结核分枝杆菌复合群的一种有用的鉴别诊断抗原。
Infect Immun. 2008 Sep;76(9):3932-9. doi: 10.1128/IAI.00150-08. Epub 2008 Jun 2.
7
Interference of paratuberculosis with the diagnosis of tuberculosis in a goat flock with a natural mixed infection.副结核病对自然混合感染山羊群中结核病诊断的干扰。
Vet Microbiol. 2008 Apr 1;128(1-2):72-80. doi: 10.1016/j.vetmic.2007.08.034. Epub 2007 Sep 18.
8
Assessment of diagnostic tools for eradication of bovine tuberculosis in cattle co-infected with Mycobacterium bovis and M. avium subsp. paratuberculosis.牛分枝杆菌和副结核分枝杆菌亚种共同感染的牛群中牛结核病根除诊断工具的评估
Vet Res. 2006 Jul-Aug;37(4):593-606. doi: 10.1051/vetres:2006021. Epub 2006 May 16.
9
Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing Mycobacterial antigen 85A and Mycobacterium bovis BCG.用表达分枝杆菌抗原85A的重组腺病毒和牛分枝杆菌卡介苗对牛进行疫苗接种所诱导的免疫反应。
Infect Immun. 2006 Feb;74(2):1416-8. doi: 10.1128/IAI.74.2.1416-1418.2006.
10
Bovine NK cells can produce gamma interferon in response to the secreted mycobacterial proteins ESAT-6 and MPP14 but not in response to MPB70.牛自然杀伤细胞可对分泌型分枝杆菌蛋白ESAT-6和MPP14产生γ干扰素应答，但对MPB70无应答。
Infect Immun. 2005 Sep;73(9):5628-35. doi: 10.1128/IAI.73.9.5628-5635.2005.

通过添加Rv3020c衍生肽改进用于牛结核病鉴别诊断的皮肤试验。

Improved skin test for differential diagnosis of bovine tuberculosis by the addition of Rv3020c-derived peptides.

作者信息

Jones Gareth J, Whelan Adam, Clifford Derek, Coad Mick, Vordermeier H Martin

机构信息

TB Research Group, Animal Health and Veterinary Laboratories Agency, New Haw, Addlestone, Surrey, United Kingdom.

出版信息

Clin Vaccine Immunol. 2012 Apr;19(4):620-2. doi: 10.1128/CVI.00024-12. Epub 2012 Feb 1.

DOI:10.1128/CVI.00024-12
PMID:22301696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3318272/
Abstract

A peptide cocktail derived from the mycobacterial antigens ESAT-6, CFP-10, and Rv3615c allowed differentiation between Mycobacterium bovis-infected and M. bovis bacillus Calmette-Guérin (BCG)-vaccinated cattle when used as a skin test reagent for a "DIVA" test (i.e., a test capable of differentiating infected and uninfected vaccinated animals). Addition of the antigen Rv3020c improves the diagnostic sensitivity without compromising specificity in the face of BCG or Johne's disease vaccination.

摘要

一种源自分枝杆菌抗原ESAT-6、CFP-10和Rv3615c的肽混合物，当用作“鉴别感染与疫苗接种动物”（DIVA）试验（即一种能够区分感染动物和未感染的接种疫苗动物的试验）的皮肤试验试剂时，可区分感染牛分枝杆菌的牛和接种卡介苗（BCG）的牛。添加抗原Rv3020c可提高诊断敏感性，同时在面对卡介苗接种或副结核菌素病疫苗接种时不影响特异性。