Kuper C Frieke, Ernst Heinrich, van Oostrum Lidy C M, Rittinghausen Susanne, Penninks André H, Ganderup Niels-Christian, Wolterbeek André P M
TNO Research Group Quality and Safety, Zeist, The Netherlands.
Toxicol Pathol. 2012 Jun;40(4):656-66. doi: 10.1177/0192623311436175. Epub 2012 Feb 1.
Histopathological examination of the nasal passages requires a standardized approach for recording lesion distribution patterns. Nasal diagrams provide guidance to map the lesions. Information on lesions exists for rodents, dogs, and monkeys, which all have been used in inhalation studies. Recently, minipigs have garnered interest as an inhalation model because minipigs resemble humans in many features of anatomy, physiology, and biochemistry and may be a good alternative to monkeys and dogs. The present work explored the microanatomy and histology of the nasal passages of Göttingen minipigs from postnatal day 1 until 6 months of age. Six nasal levels were selected, which allow examination of the squamous, transitional (nonciliated) and ciliated respiratory, and olfactory epithelia; the nasopharynx; and relevant structures such as the vomeronasal organ, olfactory bulb, and nasal/nasopharynx-associated lymphoid tissue.
鼻道的组织病理学检查需要采用标准化方法来记录病变分布模式。鼻道示意图可为绘制病变提供指导。关于啮齿动物、狗和猴子的病变信息均有记载，这些动物都曾用于吸入研究。最近，小型猪作为一种吸入模型受到关注，因为小型猪在解剖学、生理学和生物化学的许多特征上与人类相似，可能是猴子和狗的良好替代动物。本研究探讨了从出生后第1天到6月龄的哥廷根小型猪鼻道的微观解剖学和组织学。选取了六个鼻道水平，以便检查鳞状上皮、过渡性（无纤毛）和纤毛呼吸上皮以及嗅觉上皮；鼻咽；以及相关结构，如犁鼻器、嗅球和鼻/鼻咽相关淋巴组织。
