Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wu Han, China.
Dig Dis Sci. 2012 Jun;57(6):1586-97. doi: 10.1007/s10620-012-2059-x.
Epidemiological studies have suggested positive associations between diabetes and colorectal cancer. However, the findings were inconsistent, especially regarding specific sex or cancer subsite.
To conduct a systematic review with meta-analysis to examine the association of diabetes mellitus with risk of colorectal cancer and to investigate whether the association is dependent on sex, cancer subsite, race/ethnicity, or duration of diabetes.
Relevant studies were identified by searching Pubmed to May 12, 2011. The reference lists of identified articles were also reviewed. Two authors independently selected the studies and extracted relevant data. The study quality was assessed.
Thirty-nine studies (28 cohort studies and 11 case-control studies) were included in the final analysis. Compared with non-diabetic subjects, the pooled risk estimate of colorectal cancer for diabetic subjects was 1.29 (95% CI = 1.23-1.35). The subgroup analyses revealed that the risk was significantly increased for both genders, for every cancer subsite, and for both short duration and long duration of diabetes. Exposure to diabetes increased the risk of colorectal cancer for White and Asian, whereas there was no evidence of such an association either among Black or native Hawaiians.
Our results confirmed that subjects with diabetes are at modestly increased risk of developing colorectal cancer.
流行病学研究表明，糖尿病与结直肠癌之间存在正相关关系。然而，这些发现并不一致，尤其是在特定性别或癌症部位方面。
进行系统评价和荟萃分析，以检查糖尿病与结直肠癌风险之间的关联，并探讨这种关联是否依赖于性别、癌症部位、种族/民族或糖尿病的持续时间。
通过搜索 Pubmed 数据库，截至 2011 年 5 月 12 日，确定了相关研究。还对确定的文章的参考文献进行了回顾。两位作者独立选择研究并提取相关数据。评估了研究质量。
最终分析包括 39 项研究（28 项队列研究和 11 项病例对照研究）。与非糖尿病患者相比，糖尿病患者患结直肠癌的风险估计值为 1.29（95%CI=1.23-1.35）。亚组分析显示，这种风险在两性、每个癌症部位、以及糖尿病的短期和长期持续时间方面均显著增加。糖尿病暴露增加了白人和亚洲人患结直肠癌的风险，但在黑人和夏威夷原住民中没有这种关联的证据。
我们的结果证实，糖尿病患者发生结直肠癌的风险略有增加。
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