Dworakowska Dorota, Grossman Ashley B
Department of Hypertension and Diabetes, Medical University of Gdansk, Gdansk, Poland.
Guys Richard Dimbleby Department of Cancer Research, King's College London, London, United Kingdom.
Front Endocrinol (Lausanne). 2019 Jun 21;10:390. doi: 10.3389/fendo.2019.00390. eCollection 2019.
Acromegaly results in a significantly increased morbidity and mortality due to cardiovascular and respiratory complications, as well as malignancies arising mainly from the colon. Furthermore, an increased lifetime risk of malignant transformation of pre-malignant colonic lesions relates to a worse overall prognosis from colorectal cancer, which is currently considered a major disease-related complication. In this review we provide some insight into colonic changes in this condition, summarize current knowledge and evidence on the use of colonoscopic screening in patients with acromegaly, and suggest a recommended screening protocol.
肢端肥大症会因心血管和呼吸系统并发症以及主要源自结肠的恶性肿瘤而导致发病率和死亡率显著增加。此外，癌前结肠病变发生恶性转化的终生风险增加与结直肠癌总体预后较差有关，结直肠癌目前被认为是一种主要的疾病相关并发症。在本综述中，我们深入探讨了这种情况下的结肠变化，总结了目前关于肢端肥大症患者结肠镜筛查应用的知识和证据，并提出了推荐的筛查方案。
