Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Jpn J Radiol. 2012 May;30(4):370-5. doi: 10.1007/s11604-012-0055-x.
Transdermal administration of nitroglycerin (NTG) before arterial puncture may improve puncture success. The objective of this study was to evaluate the vasodilation effect of NTG skin spray on brachial arteries.
We recruited 10 healthy volunteers. On different days and in random order we sprayed their skin above the right or left brachial artery with a solution containing 0.3 mg NTG or above the right brachial artery with physiological saline. A radiologist ultrasonographically measured the cross-sectional area of right brachial artery before and at 5-min intervals for up to 25 min after spraying and calculated the rate of increase of the area.
The average vasodilation rate after spraying with NTG above the right brachial arteries of 10 volunteers was 16.4% at 5 min, 23.6% at 10 min, 19.6% at 15 min, and 16.5% at 20 min; spraying with NTG above the left brachial artery or with physiological saline alone elicited few changes. The vasodilation rate 10 min after spraying with NTG above the right brachial artery was significantly higher than for control groups (P < 0.001).
Transdermal application of NTG spray dilated the targeted brachial artery. This technique may be a good premedication before artery puncture.
动脉穿刺前经皮给予硝酸甘油（NTG）可能会提高穿刺成功率。本研究旨在评估 NTG 皮肤喷雾对肱动脉的血管扩张作用。
我们招募了 10 名健康志愿者。在不同的日子和随机顺序下，我们将含有 0.3 毫克 NTG 的溶液或生理盐水喷洒在他们右侧或左侧肱动脉上方的皮肤上。放射科医生使用超声在喷洒前和喷洒后 5 分钟间隔测量右侧肱动脉的横截面积，并计算面积增加率。
10 名志愿者右侧肱动脉喷洒 NTG 后平均血管扩张率分别为：5 分钟时 16.4%，10 分钟时 23.6%，15 分钟时 19.6%，20 分钟时 16.5%；喷洒 NTG 于左侧肱动脉或单独喷洒生理盐水时，变化较小。右侧肱动脉喷洒 NTG 10 分钟后的血管扩张率明显高于对照组（P < 0.001）。
NTG 喷雾经皮给药可扩张目标肱动脉。这种技术可能是动脉穿刺前的一种很好的预处理方法。
