Tjon J A, Ansani N T
Ann Pharmacother. 2000 Oct;34(10):1189-92. doi: 10.1345/aph.18188.
To evaluate the clinical use of transdermal nitroglycerin for the prevention of intravenous infusion failures due to phlebitis or extravasation.
Clinical literature was accessed through a MEDLINE search (1966-May 2000). Key search terms included nitroglycerin, transdermal, phlebitis, extravasation, intravenous, and infusion.
Common and serious consequences of intravenous therapy include the occurrence of postinfusion phlebitis and failure to maintain intravenous therapy due to intravenous fluid extravasation. Transdermal application of nitroglycerin has been evaluated as a treatment and preventive method for intravenous infusion failures related to phlebitis or extravasation. An evaluation of studies focusing on transdermal nitroglycerin in the prevention of infusion failures due to phlebitis or extravasation was conducted.
Use of transdermal nitroglycerin as a prophylactic measure for intravenous infusion failures is a therapeutic option for patients requiring long-term intravenous therapy (i.e., > 50 h).
评估经皮应用硝酸甘油预防因静脉炎或药物外渗导致的静脉输液失败的临床应用价值。
通过检索MEDLINE（1966年至2000年5月）获取临床文献。检索关键词包括硝酸甘油、经皮、静脉炎、外渗、静脉内、输液。
静脉治疗常见且严重的后果包括输液后静脉炎的发生以及因静脉液体外渗而无法维持静脉治疗。经皮应用硝酸甘油已被评估为一种针对与静脉炎或外渗相关的静脉输液失败的治疗和预防方法。对聚焦于经皮硝酸甘油预防因静脉炎或外渗导致的输液失败的研究进行了评估。
对于需要长期静脉治疗（即>50小时）的患者，使用经皮硝酸甘油作为预防静脉输液失败的措施是一种治疗选择。
