Laboratorio Clinico, Clinica Alemana/Universidad de Desarrollo, Santiago, Chile.
Am J Trop Med Hyg. 2012 Feb;86(2):229-32. doi: 10.4269/ajtmh.2012.11-0539.
Mannose-binding lectin (MBL) and Toll-like receptor (TLR) polymorphisms may influence susceptibility and manifestation of Trypanosoma cruzi infection. In northern Chile, we examined 61 asymptomatic patients with chronic Chagas disease (CD), 64 patients with chronic Chagas cardiomyopathy (CCC), and 45 healthy individuals. Low-producer MBL2*B genotypes were more common in CD patients (48%) than healthy individuals (31%; adjusted odds ratio = 2.3, 95% confidence interval = 1.01-5.4, P = 0.047) but did not differ with manifestation. In contrast, the heterozygous Toll-like receptor 4 (TLR4)-deficiency genotype D299G/T399I occurred more frequently in asymptomatic (14.8%) than CCC patients (3.1%; P = 0.02). TLR1-I602S, TLR2-R753Q, TLR6-S249P, and MAL/TIRAP-S180L did not associate with CD or CCC. These findings support the complement system to be involved in defense against Trypanosoma cruzi infection and indicate that curbed TLR4 activation might be beneficial in preventing CCC.
甘露糖结合凝集素 (MBL) 和 Toll 样受体 (TLR) 多态性可能影响克氏锥虫感染的易感性和表现。在智利北部，我们检查了 61 名无症状慢性恰加斯病 (CD) 患者、64 名慢性恰加斯心肌病 (CCC) 患者和 45 名健康个体。低产 MBL2*B 基因型在 CD 患者（48%）中比健康个体（31%；调整后的优势比=2.3，95%置信区间=1.01-5.4，P=0.047）更为常见，但与表现无关。相比之下，杂合 Toll 样受体 4（TLR4）缺陷基因型 D299G/T399I 在无症状患者（14.8%）中比 CCC 患者（3.1%；P=0.02）更为常见。TLR1-I602S、TLR2-R753Q、TLR6-S249P 和 MAL/TIRAP-S180L 与 CD 或 CCC 无关。这些发现支持补体系统参与防御克氏锥虫感染，并表明抑制 TLR4 激活可能有益于预防 CCC。
