Svihovcova P, Brousil J, Vitek F, Seblova J, Koprivova H, Novak F, Raban P, Dienstbier Z
Institute of Biophysics and Nuclear Medicine, Faculty of General Medicine, Charles University, Prague, CSSR.
Int J Biol Markers. 1990 Jan-Mar;5(1):1-6. doi: 10.1177/172460089000500101.
131-I-labelled anti fibrin-fibrinogen antibody (AbFbg) was compared with its F(ab')2 fragment in distribution studies and by immunoscintigraphy with a view to tumour visualization in tumour bearing rats. The distribution studies indicated that the intact antibody is more concentrated in tumour tissue than the F(ab')2 fragment. By 168h after injection, when tumour-to-tissue ratios were highest in the majority of tissues, the tumour concentration of intact antibody was 3 to 4 times that of the F(ab')2 fragment. The intact antibody is more suitable than the F(ab')2 fragment for tumour imaging especially in the abdominal region where the highest tumour-to tissue ratios were obtained with intact antibody in liver, spleen, intestines and kidneys.
在分布研究和免疫闪烁显像中，对¹³¹I标记的抗纤维蛋白-纤维蛋白原抗体（AbFbg）及其F(ab')₂片段进行了比较，目的是在荷瘤大鼠中实现肿瘤可视化。分布研究表明，完整抗体在肿瘤组织中的浓度高于F(ab')₂片段。注射后168小时，大多数组织的肿瘤与组织比值最高，此时完整抗体的肿瘤浓度是F(ab')₂片段的3至4倍。完整抗体比F(ab')₂片段更适合用于肿瘤成像，特别是在腹部区域，完整抗体在肝脏、脾脏、肠道和肾脏中获得了最高的肿瘤与组织比值。
