使用¹³¹I标记的抗纤维蛋白原抗体对实验性肿瘤进行免疫闪烁显像及分布研究。
Immunoscintigraphy and distribution study of experimental tumours using 131I-labelled anti-fibrinogen antibodies.
作者信息
Svihovcová P, Koprivová H, Glagolicová A, Novák F, Sůrová H, Dienstbier Z
出版信息
Eur J Nucl Med. 1984;9(10):478-81. doi: 10.1007/BF00563173.
131I-labelled antibodies to the fragment E of human fibrin, anti-rat fibrinogen, non-immune rabbit IgG and 67Ga-citrate were used for scintigraphy and distribution studies in experimental tumours in rats. The best visualisation was achieved with 131I-labelled anti-rat fibrinogen antibodies at intervals longer than 48 h after administration. Tumour to tissue ratios found in distribution studies performed formed more than 48 h after administration were higher in most examined tissues when using 131I-labelled antibodies than those obtained with 67Ga-citrate.
将¹³¹I标记的抗人纤维蛋白E片段抗体、抗大鼠纤维蛋白原抗体、非免疫兔IgG和枸橼酸镓用于大鼠实验性肿瘤的闪烁扫描和分布研究。给药后间隔超过48小时，¹³¹I标记的抗大鼠纤维蛋白原抗体实现了最佳显像。给药后48小时以上进行的分布研究中，在大多数检测组织中，使用¹³¹I标记抗体时肿瘤与组织的比率高于使用枸橼酸镓时获得的比率。
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