Svihovcová P, Koprivová H, Glagolicová A, Novák F, Sůrová H, Dienstbier Z
Eur J Nucl Med. 1984;9(10):478-81. doi: 10.1007/BF00563173.
131I-labelled antibodies to the fragment E of human fibrin, anti-rat fibrinogen, non-immune rabbit IgG and 67Ga-citrate were used for scintigraphy and distribution studies in experimental tumours in rats. The best visualisation was achieved with 131I-labelled anti-rat fibrinogen antibodies at intervals longer than 48 h after administration. Tumour to tissue ratios found in distribution studies performed formed more than 48 h after administration were higher in most examined tissues when using 131I-labelled antibodies than those obtained with 67Ga-citrate.
将¹³¹I标记的抗人纤维蛋白E片段抗体、抗大鼠纤维蛋白原抗体、非免疫兔IgG和枸橼酸镓用于大鼠实验性肿瘤的闪烁扫描和分布研究。给药后间隔超过48小时，¹³¹I标记的抗大鼠纤维蛋白原抗体实现了最佳显像。给药后48小时以上进行的分布研究中，在大多数检测组织中，使用¹³¹I标记抗体时肿瘤与组织的比率高于使用枸橼酸镓时获得的比率。
