Viazzi F, Leoncini G, Pontremoli R
Department of Cardionephrology, University of Genoa, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la ricerca sul Cancro, Genoa, Italy.
Reumatismo. 2012 Jan 19;63(4):253-62. doi: 10.4081/reumatismo.2011.253.
A number of epidemiological studies have reported an association between serum uric acid levels and a wide variety of high-risk conditions including hypertension, insulin resistance, and kidney and cerebro-cardiovascular disease. All things considered, serum uric acid may induce cardiovascular and kidney events both directly and indirectly by promoting other well-known mechanisms of damage. While asymptomatic hyperuricemia is currently not considered to be an indication for urate lowering therapy, there is growing evidence indicating a linear relationship between pharmacological reduction in serum uric acid and incidence of cardiovascular and renal events.
多项流行病学研究报告称，血清尿酸水平与多种高危状况相关，包括高血压、胰岛素抵抗以及肾脏和心脑血管疾病。综合考虑，血清尿酸可能通过促进其他已知的损伤机制，直接或间接地引发心血管和肾脏事件。虽然目前无症状高尿酸血症不被视为降尿酸治疗的指征，但越来越多的证据表明，血清尿酸的药物性降低与心血管和肾脏事件的发生率之间存在线性关系。
