Bochud M, Vollenweider P, Waeber G
Institut de médecine sociale et préventive, CHUV, Route de la Corniche 2, 1066 Epalinges.
Rev Med Suisse. 2011 Nov 2;7(315):2142, 2144-5.
Asymptomatic hyperuricemia affects one in five adults in the general population and is associated with elevated cardiovascular risk. It is however not clear whether asymptomatic hyperuricemia is a cause or simply a marker of conditions associated with high cardiovascular risk. Sex, age, obesity, renal function and selected drugs are major determinants of serum uric acid. Moreover, recent genome-wide association studies have identified new genes involved in the control of serum uric acid levels, in particular SLC2A9, which encodes a urate transporter located in the kidney. A genetic score based on several genetic variants associated with serum uric acid is strongly associated with the risk of gout, but not with cardiovascular events so far.
无症状性高尿酸血症影响着普通人群中五分之一的成年人，且与心血管疾病风险升高相关。然而，尚不清楚无症状性高尿酸血症是心血管高风险相关疾病的病因还是仅仅是一个标志物。性别、年龄、肥胖、肾功能和某些药物是血清尿酸的主要决定因素。此外，最近的全基因组关联研究已经确定了参与血清尿酸水平调控的新基因，特别是编码位于肾脏的尿酸转运蛋白的SLC2A9。基于与血清尿酸相关的多个基因变异的遗传评分与痛风风险密切相关，但迄今为止与心血管事件无关。
