Chen Shuang, Guo Xiaofan, Dong Siyuan, Yu Shasha, Chen Yintao, Zhang Naijin, Sun Yingxian
Department of Cardiology, The First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, People's Republic of China.
Department of Thoracic Surgery, the First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China.
Clin Rheumatol. 2017 May;36(5):1111-1119. doi: 10.1007/s10067-017-3559-z. Epub 2017 Feb 9.
The present study aimed to evaluate the relationship between the hypertriglyceridemic waist (HTGW) phenotype and hyperuricemia. We undertook a cross-sectional study with a sample of 11,576 adults from China. The HTGW phenotype was defined as elevated waist circumference (WC) and elevated triglyceride (TG) concentration. Logistic regression analysis was used to evaluate the association between the HTGW phenotype and hyperuricemia. The prevalence of hyperuricemia was significantly higher in individuals with the HTGW phenotype, as compared to those with the normal waist normal triglyceride (NWNT) group (25.9 vs. 6.1%, respectively, P < 0.001). After adjusting for age, sex, and race, the HTGW phenotype was associated with hyperuricemia (OR 6.09; 95% CI 5.18-7.17). Further adjusted for potential confounders, the HTGW phenotype was still significantly associated with hyperuricemia (adjusted OR 4.54; 95% CI 3.37-5.54). Moreover, the association between the HTGW phenotype and hyperuricemia was stronger in men (adjusted OR 4.59; 95% CI 3.53-5.98) than in women (adjusted OR 3.55; 95% CI 2.60-4.86). This study indicated that the HTGW phenotype was strongly associated with hyperuricemia, and uric acid should be clinically monitored in individuals with the HTGW phenotype. We can speculate that the HTGW phenotype might be a marker for identifying individuals at high risk of hyperuricemia.
本研究旨在评估高甘油三酯血症腰围（HTGW）表型与高尿酸血症之间的关系。我们对来自中国的11576名成年人进行了一项横断面研究。HTGW表型被定义为腰围（WC）升高和甘油三酯（TG）浓度升高。采用逻辑回归分析评估HTGW表型与高尿酸血症之间的关联。与正常腰围正常甘油三酯（NWNT）组相比，HTGW表型个体的高尿酸血症患病率显著更高（分别为25.9%和6.1%，P < 0.001）。在调整年龄、性别和种族后，HTGW表型与高尿酸血症相关（比值比6.09；95%置信区间5.18 - 7.17）。进一步调整潜在混杂因素后，HTGW表型仍与高尿酸血症显著相关（调整后比值比4.54；95%置信区间3.37 - 5.54）。此外，HTGW表型与高尿酸血症之间的关联在男性中（调整后比值比4.59；95%置信区间3.53 - 5.98）比在女性中（调整后比值比3.55；95%置信区间2.60 - 4.86）更强。本研究表明，HTGW表型与高尿酸血症密切相关，临床上应对HTGW表型个体进行尿酸监测。我们可以推测，HTGW表型可能是识别高尿酸血症高危个体的一个标志物。
