Cişleanu Diana, Onisâi Minodora, Vlădăreanu Ana-Maria, Găman Mihaela, Neagul Ana-Maria, Bumbea H, Iova Anamaria, Baluţa Cristina, Cazaceanu Oana, Begu Mădălina, Ilea Anca
Hematology Department, Emergency University Hospital Bucharest, Romania.
Rom J Intern Med. 2011;49(2):137-44.
We present the case of a patient with a double transformation during the evolution of chronic hematopoietic malignancy - JAK2 positive chronic myeloproliferative neoplasm; the first transformation had occurred previous to the presentation in our Department, but the second transformation was observed in evolution and it was into a rapidly evolving disease, followed by survival of less than one month. We underline the very poor prognosis -- overall survival of 2.5 years from initial presentation -- a much reduced survival for a chronic myeloproliferative neoplasm, probably due also to multiple associated pathology. Also, the other interesting element of the case is related to the dysfunctional platelets -- hemorrhagic complication at increased platelet count, respectively thrombosis at platelet count under 20000/mmc.
