Sun Quiang, Peng De-fu, Zheng Jia-fa
Department of Orthopedics, Zhongshan Hospital Affiliated to Dalian University, Dalian (10600).
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Nov;31(11):1463-5.
To observe the therapeutic effect of the low molecular weight heparin calcium (LMWHC) combined with Yinxin Damo Injection (YDI) on the prevention of deep venous thrombosis (DVT) after the operation of intertrochanteric fracture.
Sixty-two patients with intertrochanteric fracture were randomly assigned to the control group and the combined group, 31 in each group. Patients in the control group were subcutaneously injected with 6 000 IU LMWHC, twice daily. On this basis of the aforesaid treatment, patients in the combined group were intravenously dripped with YDI at the daily dose of 20 mL, once daily. The treatment lasted for 10 days in both groups. The DVT incidence rate, postoperative drainage amount of blood, activated partial thromboplastin time (APTT), plasma prothrombin time (PT), platelet count, and the maximal swelling rate of lower limbs after surgery were compared between the two groups after operation.
In the control group DVT occurred in 5 cases (16. 1%) while it occurred in 2 cases (6.5%) in the combined group, showing significant differences (P < 0.05). Both APTT and PT were shortened in the two groups on the 2nd day after medication (P < 0.01). Compared with the control group, it was more obvious in the combined group, showing statistical significance (P < 0.05). Both APTT and PT were shortened in the control group on the 10th day after medication when compared with before treatment (P < 0.01). But they were postponed in the combined group when compared with before medication, showing statistical difference when compared with the control group (P < 0.05). The platelet count increased in the combined group on the 10th day after medication. Besides, it was higher than that in the control group, showing statistical difference (P < 0.05). The platelet counts were in the normal range.
LMWSC combined with YDI could not only reduce the incidence of DVT after the operation of intertrochanteric fracture, but also change the state of higher blood coagulation. It showed significant effect on preventing DVT after the operation of intertrochanteric fractures.
观察低分子肝素钙联合银杏达莫注射液预防股骨粗隆间骨折术后深静脉血栓形成的疗效。
将62例股骨粗隆间骨折患者随机分为对照组和联合组，每组31例。对照组患者皮下注射低分子肝素钙6000IU，每日2次。联合组患者在上述治疗基础上，静脉滴注银杏达莫注射液，每日剂量20mL，每日1次。两组均治疗10天。比较两组术后深静脉血栓发生率、术后引流量、活化部分凝血活酶时间（APTT）、血浆凝血酶原时间（PT）、血小板计数及术后下肢最大肿胀率。
对照组发生深静脉血栓5例（16.1%），联合组发生2例（6.5%），差异有统计学意义（P<0.05）。两组用药后第2天APTT和PT均缩短（P<0.01），联合组较对照组更明显，差异有统计学意义（P<0.05）。对照组用药后第10天APTT和PT较治疗前缩短（P<0.01），联合组较用药前延长，与对照组比较差异有统计学意义（P<0.05）。联合组用药后第10天血小板计数升高，且高于对照组，差异有统计学意义（P<0.05），血小板计数均在正常范围内。
低分子肝素钙联合银杏达莫注射液不仅能降低股骨粗隆间骨折术后深静脉血栓的发生率，还能改善高凝状态，对预防股骨粗隆间骨折术后深静脉血栓形成有显著效果。
