Khamaeva A A, Belialov F I, Kerzina L V, Berezovskaia O V, Parshukova E D, Zakharova G Iu
Kardiologiia. 2012;52(1):15-9.
We investigated impact of ivabradine on exercise capacity and quality of life in patients with stable angina and comorbid chronic obstructive pulmonary disease during treatment with -blockers. Ivabradine with -blockers reduced heart rate, increased exercise capacity and improved angina more effective than -blockers only. Quality of life associated with angina increased in patients with stage I and II chronic obstructive pulmonary disease. Addition of ivabradine to -blockers for 2 month did not produce adverse respiratory effects.
我们研究了伊伐布雷定对在使用β受体阻滞剂治疗期间患有稳定型心绞痛合并慢性阻塞性肺疾病患者的运动能力和生活质量的影响。伊伐布雷定联合β受体阻滞剂比单用β受体阻滞剂更能降低心率、提高运动能力并更有效地改善心绞痛。I期和II期慢性阻塞性肺疾病患者中与心绞痛相关的生活质量有所提高。在β受体阻滞剂基础上加用伊伐布雷定2个月未产生不良呼吸影响。
