Antioxid Redox Signal. 2012 Jun 1;16(11):1212-4. doi: 10.1089/ars.2012.4532. Epub 2012 Mar 2.
Cancer development, progression, and metastasis are multistep processes. Accumulating evidence suggests that reactive oxygen species (ROS) are critically involved in cancer cell functions. This Forum reviews our current understanding of the important and paradoxical role of ROS in the regulation of tumor-associated cell properties, genes, and signaling pathways. The six reviews in this Forum showcase the up-to-date knowledge on how ROS modulate or interact with the p53 protein, epithelial-mesenchymal transition, tumor stromal cells, angiogenesis, and cancer stem cells, which are essential factors in cancer development and metastasis. The contributions demonstrate that ROS levels in cancer cells are tightly controlled, which brings promises and challenges in the development of novel ROS-targeted anticancer therapies. Further understanding of the biological mechanisms underlying the effects of oxidative stress on tumor growth and metastasis will contribute to the advancement of cancer biology and cancer treatment.
癌症的发生、发展和转移是多步骤的过程。越来越多的证据表明，活性氧（ROS）在癌细胞功能中起着至关重要的作用。本论坛综述了我们目前对 ROS 在调节肿瘤相关细胞特性、基因和信号通路中的重要而矛盾作用的理解。本论坛的六篇综述展示了最新的知识，即 ROS 如何调节或与 p53 蛋白、上皮-间充质转化、肿瘤基质细胞、血管生成和癌症干细胞相互作用，这些都是癌症发生和转移的重要因素。这些贡献表明，癌细胞中的 ROS 水平受到严格控制，这为开发新型 ROS 靶向抗癌疗法带来了希望和挑战。进一步了解氧化应激对肿瘤生长和转移影响的生物学机制将有助于推进癌症生物学和癌症治疗的发展。
