免疫细胞利用神经回路进入中枢神经系统。
Immune cells exploit a neural circuit to enter the CNS.
机构信息
Laboratory of Biomedical Science, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA.
出版信息
Cell. 2012 Feb 3;148(3):392-4. doi: 10.1016/j.cell.2012.01.025.
Abstract
Multiple sclerosis (MS) is associated with the appearance of autoreactive T cells in the central nervous system. Using a mouse model of MS, Arima et al. now show that this attack begins at a specific spinal cord location. T cell entry into the CNS is regulated by a reflex neural circuit originating from leg muscle contractions.
摘要
多发性硬化症（MS）与中枢神经系统中自身反应性 T 细胞的出现有关。Arima 等人在 MS 的小鼠模型中表明，这种攻击始于特定的脊髓位置。T 细胞进入中枢神经系统受到源自腿部肌肉收缩的反射神经回路的调节。
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本文引用的文献
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