Tanaka Yuki, Arima Yasunobu, Kamimura Daisuke, Murakami Masaaki
Molecular Psychoimmunology, Graduate School of Medicine, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
Front Immunol. 2017 Oct 18;8:1321. doi: 10.3389/fimmu.2017.01321. eCollection 2017.
The gateway reflex is a new phenomenon that explains how immune cells bypass the blood-brain barrier to infiltrate the central nervous system (CNS) and trigger neuroinflammation. To date, four examples of gateway reflexes have been discovered, each described by the stimulus that evokes the reflex. Gravity, electricity, pain, and stress have all been found to create gateways at specific regions of the CNS. The gateway reflex, the most recently discovered of the four, has also been shown to upset the homeostasis of organs in the periphery through its action on the CNS. These reflexes provide novel therapeutic targets for the control of local neuroinflammation and organ function. Each gateway reflex is activated by different neural activations and induces inflmammation at different regions in the CNS. Therefore, it is theoretically possible to manipulate each independently, providing a novel therapeutic strategy to control local neuroinflammation and peripheral organ homeostasis.
通路反射是一种新现象，它解释了免疫细胞如何绕过血脑屏障浸润中枢神经系统（CNS）并引发神经炎症。迄今为止，已发现了四个通路反射的例子，每个例子都由引发该反射的刺激来描述。重力、电、疼痛和压力都已被发现会在中枢神经系统的特定区域形成通路。通路反射是这四个中最新发现的，它还通过对中枢神经系统的作用扰乱外周器官的稳态。这些反射为控制局部神经炎症和器官功能提供了新的治疗靶点。每个通路反射由不同的神经激活所激活，并在中枢神经系统的不同区域诱发炎症。因此，理论上有可能对每个反射进行独立操控，从而提供一种控制局部神经炎症和外周器官稳态的新治疗策略。
