Chraïbi M, Elkhoury R, Abd Alsamad I
Service d'anatomie et de cytologie pathologique, centre hospitalier intercommunal, Créteil, France.
Rev Pneumol Clin. 2012 Feb;68(1):23-6. doi: 10.1016/j.pneumo.2010.11.009. Epub 2011 Apr 29.
Desmoplastic mesothelioma is unusual variant of malignant mesothelioma. The diagnosis of desmoplastic mesothelioma represents one of the most difficult exercises in pleural pathology (with poor interobservers agreement) because of their abundant collagen with relatively low cellularity. The clinical course is often rapid with visceral metastases. Bony metastases have only rarely been noted. We report our case of desmoplastic mesothelioma with vertebral metastases. Our focus is to distinguish this entity from fibrous pleurisy and localized fibrous tumors, to explain histological and immunohistochemical features with review of the literature.
促纤维增生性间皮瘤是恶性间皮瘤的一种罕见变体。由于促纤维增生性间皮瘤富含胶原蛋白且细胞密度相对较低，其诊断是胸膜病理学中最具挑战性的任务之一（观察者间一致性较差）。临床病程通常较快，常伴有内脏转移。骨转移很少见。我们报告了一例伴有椎体转移的促纤维增生性间皮瘤病例。我们的重点是将该实体与纤维性胸膜炎和局限性纤维瘤相鉴别，并结合文献回顾解释其组织学和免疫组化特征。
