Gering S A, Folts J D
Department of Medicine, University of Wisconsin, Madison.
J Lab Clin Med. 1990 Nov;116(5):728-36.
The tobacco industry proposes to release a "new" cigarette with a burning charcoal tip, which heats the tobacco as air is drawn through it and into the lungs of the smoker. It is claimed to be safer because the tobacco does not burn. Using our established canine model of coronary artery stenosis with moderate intimal damage, we compared this new cigarette (0.4 mg nicotine) with a regular cigarette by ventilating dogs (n = 10) with room air and then either new or regular smoke (two cigarettes over about 10 minutes). In our dog model, periodic acute platelet thrombus formation followed by embolization produced cyclical flow reductions in coronary blood flow where the rate of flow decline was proportional to the degree of in vivo platelet-vessel wall interaction. The rate of flow decline increased from -4.81 +/- 1.29 ml/min2 to -9.60 +/- 2.29 ml/min2 after ventilation with the new-type smoke (p less than 0.01). Similarly, the rate of flow decline increased from -5.43 +/- 1.28 ml/min2 to -9.28 +/- 2.31 ml/min2 after ventilation with regular cigarette smoke (p less than 0.01). Despite the lack of a clear causal link between cigarette smoking and the acute manifestations of cardiovascular disease, the data presented here indicate that the new cigarette is just as potent as regular cigarettes at increasing in vivo platelet activity and exacerbating acute platelet thrombus formation in the dog. We conclude that the new proposed non-tobacco-burning cigarette has deleterious effects similar to those of conventional cigarettes, and thus does not eliminate smoking as a risk factor in cardiovascular disease in human beings.
烟草行业提议推出一种带有燃烧炭头的“新型”香烟，当空气通过炭头吸入并进入吸烟者肺部时，炭头会加热烟草。据称这种香烟更安全，因为烟草不会燃烧。我们使用已建立的犬类冠状动脉狭窄伴中度内膜损伤模型，通过让10只狗吸入室内空气，然后吸入新型香烟（尼古丁含量0.4毫克）或普通香烟（约10分钟内吸两支），对这种新型香烟和普通香烟进行了比较。在我们的犬类模型中，周期性急性血小板血栓形成并随后发生栓塞，导致冠状动脉血流出现周期性减少，血流下降速率与体内血小板与血管壁相互作用的程度成正比。吸入新型香烟后，血流下降速率从-4.81±1.29毫升/分钟²增加到-9.60±2.29毫升/分钟²（p<0.01）。同样，吸入普通香烟烟雾后，血流下降速率从-5.43±1.28毫升/分钟²增加到-9.28±2.31毫升/分钟²（p<0.01）。尽管吸烟与心血管疾病的急性表现之间缺乏明确的因果联系，但此处呈现的数据表明，新型香烟在增加犬类体内血小板活性和加剧急性血小板血栓形成方面与普通香烟一样有效。我们得出结论，新提议的不燃烧烟草的香烟具有与传统香烟类似的有害影响，因此并不能消除吸烟作为人类心血管疾病风险因素的问题。
