Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea.
J Stroke Cerebrovasc Dis. 2012 Nov;21(8):913.e9-10. doi: 10.1016/j.jstrokecerebrovasdis.2012.01.005. Epub 2012 Feb 3.
Although essential thrombocythemia (ET) may involve thrombotic complications, including arterial or venous thrombosis, there are no reports of major vascular complications, including both arterial and venous thrombosis, in a patient with ET. We report on a patient with a cerebral infarction affecting the right lateral thalamus and a stenotic lesion of the right posterior cerebral artery. This arterial thrombotic event may be related to ET, which was based on results of a bone marrow biopsy specimen. The patient had experienced previous events of thrombosis, splenic infarction with venous thrombosis, and myocardial infarction. The cause of recurrent ischemic events involving both arterial and venous systems may be sustained elevation of platelet counts. Previous thrombosis is an established risk factor for rethrombosis in patients with ET. Efficient cytoreductive therapy with an antiplatelet agent should be considered for the prevention of recurrent thrombosis.
虽然特发性血小板增多症（ET）可能涉及血栓并发症，包括动脉或静脉血栓形成，但尚无 ET 患者发生包括动脉和静脉血栓形成在内的主要血管并发症的报告。我们报告了一例影响右侧外侧丘脑和右侧大脑后动脉狭窄病变的脑梗死患者。这种动脉血栓形成事件可能与骨髓活检结果提示的 ET 有关。该患者曾经历过血栓形成、脾梗死伴静脉血栓形成和心肌梗死等先前的血栓事件。导致涉及动脉和静脉系统的复发性缺血事件的原因可能是血小板计数持续升高。先前的血栓形成是 ET 患者再血栓形成的既定危险因素。应考虑使用抗血小板药物进行有效的细胞减少治疗，以预防复发性血栓形成。
