INSERM, U708, Neuroepidemiology, F-75005, Paris, France.
Neuroimage. 2012 Apr 2;60(2):871-8. doi: 10.1016/j.neuroimage.2012.01.102. Epub 2012 Jan 28.
Cerebral white matter lesions are associated with poorer motor performances in the elderly, but the role of gray matter atrophy remains largely unknown. We investigated the cross-sectional relation between brain regional gray matter volumes and walking speed over 6m in the 3C-Dijon study, a large population-based study of community-dwelling persons aged 65 years and over (N=1623). Regional gray matter volumes were obtained using an automated anatomical labeling parcellation method. Multivariable analyses were performed using a semi-Bayes approach. After adjustment for potential confounders, persons who walked slower had a smaller volume of basal ganglia (regression coefficient [β]=0.054, standard error [SE]=0.028, p=0.05). In more detailed analyses, the volume of the caudate nucleus had a preponderant role on this association (β=0.049, SE=0.019, p=0.009), and walking speed decreased progressively with the volume of the caudate nucleus (p for linear trend<0.001). These results underline the role of gray matter subcortical structures, in particular of the caudate nucleus, in the age-related decline of motor performances among community-dwelling elderly subjects.
脑白质病变与老年人运动表现较差有关，但灰质萎缩的作用在很大程度上仍不清楚。我们在 3C-Dijon 研究中调查了大脑区域灰质体积与 6m 行走速度之间的横断面关系，该研究是一项针对 65 岁及以上社区居住人群的大型基于人群的研究（N=1623）。使用自动解剖标记分区方法获得区域灰质体积。使用半贝叶斯方法进行多变量分析。在调整潜在混杂因素后，行走速度较慢的人基底节体积较小（回归系数[β]=0.054，标准误差[SE]=0.028，p=0.05）。在更详细的分析中，尾状核体积在这种关联中起主导作用（β=0.049，SE=0.019，p=0.009），并且行走速度随尾状核体积的增加而逐渐降低（线性趋势的 p<0.001）。这些结果强调了灰质皮质下结构，特别是尾状核，在社区居住的老年受试者中与年龄相关的运动表现下降中的作用。
