van Es Adriaan C G M, van der Grond Jeroen, de Craen Anton J M, Admiraal-Behloul Faiza, Blauw Gerard J, van Buchem Mark A
Department of Radiology, C2-S, Leiden University Medical Center, RC Leiden, The Netherlands. A.C.G.M.van
Neurobiol Aging. 2008 Dec;29(12):1839-46. doi: 10.1016/j.neurobiolaging.2007.05.008. Epub 2007 Jun 28.
In this study we investigated patterns of hypointense basal ganglia on T2*-weighted magnetic resonance imaging (MRI) in 413 non-demented elderly (range: 70-82 years, mean 77 years; male/female: 177/239). In addition, we assessed associations between these patterns and age-related changes in the brain. Three patterns were noted: hypointensity limited to the globus pallidus (group I; n=30; 7%), hypointensity of both globus pallidus and putamen (group II; n=272; 66%), and hypointensity of globus pallidus, putamen and caudate nucleus (group III; n=111; 27%). Group III demonstrated a higher volume of white matter hyperintensities, more atrophy, decreased whole brain magnetization transfer ratios and increased T2-values compared to groups I and II. No differences were observed between groups I and II. From this study we conclude that hypointensity of the caudate nucleus is associated with a higher load of age-related cerebral changes. These data suggest that hypointensity of the caudate nucleus could be a new biomarker of age-related changes in the brain.
在本研究中，我们调查了413名非痴呆老年人（年龄范围：70 - 82岁，平均77岁；男性/女性：177/239）在T2*加权磁共振成像（MRI）上基底节低信号的模式。此外，我们评估了这些模式与大脑中与年龄相关变化之间的关联。观察到三种模式：低信号仅限于苍白球（I组；n = 30；7%），苍白球和壳核均有低信号（II组；n = 272；66%），以及苍白球、壳核和尾状核均有低信号（III组；n = 111；27%）。与I组和II组相比，III组显示出更大体积的白质高信号、更多萎缩、全脑磁化传递率降低以及T2值升高。I组和II组之间未观察到差异。从本研究中我们得出结论，尾状核低信号与更高负荷的与年龄相关的脑变化有关。这些数据表明，尾状核低信号可能是大脑中与年龄相关变化的一种新的生物标志物。
