Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, United States.
Biomaterials. 2012 Apr;33(12):3388-400. doi: 10.1016/j.biomaterials.2012.01.014. Epub 2012 Feb 4.
With the high occurrence of cardiovascular disease and increasing numbers of patients requiring vascular access, there is a significant need for a small-diameter (<6 mm inner diameter) vascular graft that can provide long-term patency. Tissue engineering provides a very promising solution to this need. Approaches utilizing adult stem cells can address limitations previously realized in the use of terminally differentiated vascular cells, without introducing the ethical concerns that continue to limit the exploration and use of embryonic stem cells. This review summarizes the exciting work that has been reported on the application of adult stem cells to tissue engineered vascular grafts. Work in this area to date has employed bone marrow mononuclear progenitor cells, mesenchymal stem cells from various sources, and endothelial precursor cells.
随着心血管疾病的高发和需要血管通路的患者数量不断增加，对于能够提供长期通畅性的小直径（<6 毫米内径）血管移植物存在着巨大的需求。组织工程学为此提供了一个非常有前途的解决方案。利用成体干细胞的方法可以解决以前在使用终末分化的血管细胞时所遇到的限制，同时避免了继续限制胚胎干细胞的探索和使用所带来的伦理问题。这篇综述总结了目前在应用成体干细胞构建组织工程血管移植物方面的令人兴奋的工作。迄今为止，该领域的工作已经使用了骨髓单核细胞前体细胞、各种来源的间充质干细胞和内皮祖细胞。
