健康成年女性血清 Amphiregulin 的正常范围。
Normal range of serum Amphiregulin in healthy adult human females.
机构信息
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
出版信息
Clin Biochem. 2012 Apr;45(6):460-3. doi: 10.1016/j.clinbiochem.2011.12.029. Epub 2012 Jan 28.
OBJECTIVES
Prior to large studies in breast cancer patients, we have sought to establish the normal range of a potential serum biomarker, Amphiregulin, in healthy women and to determine whether sampling during the menstrual cycle influences the detected Amphiregulin levels.
DESIGN AND METHODS
Serum Amphiregulin levels were quantified using a commercially available ELISA in 85 normal female donors.
RESULTS
The range of circulating Amphiregulin was 0-4467 pg/mL. The majority of women had no detectable circulating Amphiregulin (n=54), and only five women had levels exceeding 500 pg/mL. Serum Amphiregulin levels did not vary significantly during the menstrual cycle (n=7 women).
CONCLUSIONS
Detection of circulating Amphiregulin in a significant minority of healthy women suggests that it may not have the specificity necessary for a population screening tool; however its potential utility for monitoring response to treatment or disease progression should be examined in breast cancer cases.
目的
在针对乳腺癌患者的大型研究之前，我们试图确定一种潜在的血清生物标志物 Amphiregulin 在健康女性中的正常范围，并确定月经周期期间的采样是否会影响检测到的 Amphiregulin 水平。
设计和方法
使用商业上可用的 ELISA 在 85 名正常女性供体中定量血清 Amphiregulin 水平。
结果
循环 Amphiregulin 的范围为 0-4467 pg/mL。大多数女性没有检测到循环 Amphiregulin（n=54），只有 5 名女性的水平超过 500 pg/mL。血清 Amphiregulin 水平在月经周期中没有显著变化（n=7 名女性）。
结论
在少数健康女性中检测到循环 Amphiregulin 表明它可能不具有作为人群筛查工具所需的特异性；然而，在乳腺癌病例中，应该检查其用于监测治疗反应或疾病进展的潜在效用。
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