Institute of Medical Psychology, Shandong University Medical School, Jinan 250012, PR China.
Neurosci Lett. 2012 Mar 9;511(2):95-100. doi: 10.1016/j.neulet.2012.01.046. Epub 2012 Jan 28.
The coordinated responses of the sympathoadreno-medullary (SAM) system and hypothalamic-pituitary-adrenal (HPA) axis could improve the organism's capacity to cope with stress, but its underlying mechanism is still unclear. In the present study, 32 Wistar rats were employed and divided into four groups: control, CUMS, PROP and PRAZ. After the chronic unpredicted mild stress (CUMS) model was built in the latter three groups, all animals were exposed to inescapable footshock. We found that α(1)-adrenoceptor antagonist prazosin (PRAZ) administration could improve behavior changes, reduce the cellular impairment in brain and inhibit the hyperfunction of HPA axis induced by CUMS exposure. Moreover, it decreased the heat shock protein 70 and inducible nitric oxide synthase expression in different brain areas as subsequently exposed to acute stress. In conclusion, α1-adrenoceptor may play a major role in regulating the coordinated responses between two physiological axes and improve the stress resistance.
交感肾上腺髓质（SAM）系统和下丘脑-垂体-肾上腺（HPA）轴的协调反应可以提高机体应对压力的能力，但其潜在机制尚不清楚。本研究采用 32 只 Wistar 大鼠，随机分为 4 组：对照组、CUMS 组、PROP 组和 PRAZ 组。在后 3 组建立慢性不可预测轻度应激（CUMS）模型后，所有动物均接受不可逃避的足底电击。我们发现，α(1)-肾上腺素能受体拮抗剂特拉唑嗪（PRAZ）可改善行为改变，减轻脑损伤，并抑制 CUMS 暴露引起的 HPA 轴功能亢进。此外，它还降低了不同脑区在随后暴露于急性应激时热休克蛋白 70 和诱导型一氧化氮合酶的表达。综上所述，α1-肾上腺素能受体可能在调节两个生理轴之间的协调反应和提高应激抗性方面发挥主要作用。
