State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Molecules. 2012 Feb 3;17(2):1425-36. doi: 10.3390/molecules17021425.
The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C.DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were identified as potent and safe antidepressant lead compounds.
首次全合成了从 Piper laetispicum C.DC（胡椒科）茎中分离得到的酰胺生物碱 laetispicine（1a），并合成了一些衍生物。基于在强迫游泳试验中对抗抑郁活性的评估，化合物 1h 和 1i 被鉴定为具有潜力和安全的抗抑郁先导化合物。
