Unité des Aspergillus, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France.
Fungal Genet Biol. 2012 Mar;49(3):210-6. doi: 10.1016/j.fgb.2012.01.005. Epub 2012 Jan 28.
We recently reported on DprA and DprB, dehydrin-like proteins involved in the protection against oxidative, osmotic and pH stress in Aspergillus fumigatus. A third dehydrin-like gene, DprC, was detected in the genome of the filamentous fungus and repressed during conidial germination. The deletion mutant was impaired in freezing tolerance. The DprC-mediated response was dependent on the SakA MAP kinase pathway, and accordingly, SakA phosphorylation was induced by cold shock. When fused to eGFP, the protein was associated with the vacuoles.
我们最近报道了 DprA 和 DprB，它们是参与保护烟曲霉免受氧化、渗透和 pH 应激的脱水素样蛋白。在丝状真菌的基因组中检测到第三个脱水素样基因 DprC，它在分生孢子萌发过程中受到抑制。该缺失突变体在抗冻能力方面受损。DprC 介导的反应依赖于 SakA MAP 激酶途径，因此，冷休克诱导了 SakA 的磷酸化。当与 eGFP 融合时，该蛋白与液泡相关。
