Laboratorio de Hígado, Páncreas y Motilidad (HIPAM), Department of Experimental, Medicine-Faculty of Medicine, Universidad Nacional Autónoma de México, Hospital General de México, Mexico, Mexico.
Am J Gastroenterol. 2012 Feb;107(2):273-5. doi: 10.1038/ajg.2011.427.
Evidences suggest that there is low-grade inflammation in the colonic mucosa and/or a state of immune activation in patients with irritable bowel syndrome (IBS). Results from available studies are inconsistent mainly because of differences in measures, methodologies and study populations. In this issue, Chang et al. evaluated a comprehensive set of cytokines, immune markers and immune-related cells in patients with non post infectious IBS (non PI-IBS) and controls. The main finding was a lower expression of the mRNA of the anti-inflammatory IL-10 cytokine in the colonic mucosa of women with non PI-IBS without any differences in the cell counts. These results suggest that in non PI-IBS, there is altered immune regulation/activation without evidence of low-grade mucosal inflammation. Further, PI and non PI-IBS may be associated with different alterations in immune function/activation.
有证据表明，在肠易激综合征（IBS）患者的结肠黏膜中存在低度炎症和/或免疫激活状态。由于测量方法、方法学和研究人群的差异，现有研究的结果并不一致。在本期杂志中，Chang 等人评估了一组非感染后肠易激综合征（非 PI-IBS）患者和对照组患者的细胞因子、免疫标志物和免疫相关细胞。主要发现是在非 PI-IBS 女性的结肠黏膜中抗炎细胞因子 IL-10 的 mRNA 表达较低，而细胞计数没有差异。这些结果表明，在非 PI-IBS 中，存在免疫调节/激活的改变，而没有低度黏膜炎症的证据。此外，PI 和非 PI-IBS 可能与免疫功能/激活的不同改变有关。
