Devor E J
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110.
J Nerv Ment Dis. 1990 Nov;178(11):669-79. doi: 10.1097/00005053-199011000-00001.
A review of the current status of the genetics of Tourette syndrome is presented. Over the course of the 104 years since Gilles de la Tourette described the syndrome that bears his name, a body of carefully collected, described, and analyzed data has produced a model of the genetics that implicates a single dominant gene that is variably penetrant in males and females. Moreover, the locus of action of this gene is most likely in the dopaminergic system of the midbrain. A systematic search for this gene using recombinant DNA techniques is under way.
本文对抽动秽语综合征的遗传学现状进行了综述。自吉尔斯·德拉·图雷特描述了以他名字命名的综合征后的104年里，一系列经过精心收集、描述和分析的数据形成了一个遗传学模型，该模型表明存在一个单一的显性基因，在男性和女性中具有不同的外显率。此外，该基因的作用位点很可能位于中脑的多巴胺能系统中。目前正在使用重组DNA技术对该基因进行系统搜索。
