Adrianto Indra, Montgomery Courtney
Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Methods Mol Biol. 2012;850:59-76. doi: 10.1007/978-1-61779-555-8_5.
Methods of estimating allele frequencies from data on unrelated and related individuals are described in this chapter. For samples of unrelated individuals with simple codominant markers, the natural estimator of allele frequencies can be used. For genetic data on related individuals, maximum likelihood estimation (MLE) can be applied to compute allele frequencies. Factors that influence allele frequencies in populations are also explained.
本章介绍了根据无关个体和相关个体的数据估计等位基因频率的方法。对于具有简单共显性标记的无关个体样本，可以使用等位基因频率的自然估计器。对于相关个体的遗传数据，可以应用最大似然估计（MLE）来计算等位基因频率。文中还解释了影响群体中等位基因频率的因素。
