Verweij Karin J H, Mosing Miriam A, Zietsch Brendan P, Medland Sarah E
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, QLD, Australia.
Methods Mol Biol. 2012;850:151-70. doi: 10.1007/978-1-61779-555-8_9.
This chapter describes how the heritability of a trait can be estimated using data collected from pairs of twins. The principles of the classical twin design are described, followed by the assumptions and possible extensions of the design. In the second part of this chapter, two example scripts are presented and described, explaining the basic steps for estimating heritability using the statistical program OpenMx. OpenMx and the scripts used for this chapter can be downloaded so that readers can adapt and use the scripts for their own purposes.
本章描述了如何使用从双胞胎对收集的数据来估计性状的遗传力。阐述了经典双胞胎设计的原理,随后介绍了该设计的假设和可能的扩展。在本章的第二部分,给出并描述了两个示例脚本,解释了使用统计程序OpenMx估计遗传力的基本步骤。可以下载OpenMx和本章使用的脚本,以便读者根据自己的目的对脚本进行调整和使用。