神经节苷脂GD3在人脑膜瘤中的表达与22号染色体单体性相关。

Expression of the ganglioside GD3 in human meningiomas is associated with monosomy of chromosome 22.

作者信息

Fredman P, Dumanski J, Davidsson P, Svennerholm L, Collins V P

机构信息

Department of Psychiatry and Neurochemistry, St. Jörgen Hospital, Hisings Backa, Sweden.

出版信息

J Neurochem. 1990 Dec;55(6):1838-40. doi: 10.1111/j.1471-4159.1990.tb05765.x.

DOI:10.1111/j.1471-4159.1990.tb05765.x

PMID:2230798

Abstract

The ganglioside composition of 59 meningiomas has been compared with a molecular genetic analysis of chromosome 22 in the same specimens. Major gangliosides were GM3 (II3NeuAc-LacCer) and/or GD3 [II3(NeuAc)2-LacCer]. In specimens with no or partial deletions of chromosome 22, the GM3 ganglioside predominated, and the mean value for GM3, 61% of total sialic acid, was around four times higher than that for GD3. A loss of chromosome 22, found in 56% of the specimens, was shown to be associated with an increase in the proportion of ganglioside GD3, with the ratio between mean values of GM3 and GD3 being approximately 1:1. Logistic regression revealed that the probability of predicting monosomy of chromosome 22 by the GD3 proportion was 66%.

摘要

对59例脑膜瘤的神经节苷脂成分与相同标本中22号染色体的分子遗传学分析进行了比较。主要神经节苷脂为GM3（II3NeuAc-LacCer）和/或GD3 [II3(NeuAc)2-LacCer]。在22号染色体无缺失或部分缺失的标本中，GM3神经节苷脂占主导，GM3占总唾液酸的平均值为61%，约为GD3的四倍。在56%的标本中发现22号染色体缺失，这与神经节苷脂GD3比例的增加有关，GM3和GD3平均值之比约为1:1。逻辑回归显示，通过GD3比例预测22号染色体单体性的概率为66%。