辐射诱发的脑膜瘤中的22号染色体单体性
Chromosome 22 monosomy in a radiation-induced meningioma.
作者信息
Pagni C A, Canavero S, Fiocchi F, Ponzio G
机构信息
Istituto di Neurochirurgia, Università di Torino.
出版信息
Ital J Neurol Sci. 1993 Jun;14(5):377-9. doi: 10.1007/BF02340725.
PMID:8354634
Abstract
We report for the first time on the cytogenetics of a radiation-induced meningioma, in a patient without neurofibromatosis. Chromosome 22 monosomy was found in more than 50% of the cells examined. These findings seem to suggest that the same kind of chromosomal aberrations are found in both "idiopathic" and radiation-induced meningiomas and that a common etiopathogenetic mechanism might be at work in meningiomas of whatever origin.
摘要
我们首次报告了一例无神经纤维瘤病患者辐射诱发脑膜瘤的细胞遗传学情况。在所检查的细胞中，超过50%发现有22号染色体单体性。这些发现似乎表明，在“特发性”和辐射诱发的脑膜瘤中都发现了同样类型的染色体畸变，并且无论起源如何，脑膜瘤可能存在共同的病因发病机制。
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