Nazari Mohammad Abbasi, Malayeri Sahar Hasani, Pourhoseingholi Mohammad Amin, Mohebi Seyed Reza, Zali Mohammad Reza
Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hepat Mon. 2010 Winter;10(1):62-4. Epub 2010 Mar 1.
Zinc (Zn) has various significant roles in physiological functions of the liver. Furthermore, it has been reported that the administration of zinc has an important role in pharmacotherapy of viral hepatitis. Cirrhotic patients with decrease in plasma zinc level have been covered in previous studies. It is seemingly necessary to assess the zinc level, in Iranian cirrhotic patients, as a distinct population, Because of the large phytate amounts in Iranians diet. Regarding to etiology, disease progress, and treatment, there are some differences in the 2 most common causes of cirrhosis in the Iranian population (hepatitis B and hepatitis C) and it is possible that the zinc level may be different between the two. This study was done to shadow some lights on the subject.
Between April 2008 and November 2008, plasma zinc level was determined, by atomic absorption method, in 60 cirrhotic inpatients treated due to hepatitis B or hepatitis C in Talighani hospital (a referral center for gastrontestinal and liver diseases in Tehran, Iran).
Mean ± standard deviation (SD) plasma zinc levels determined 0.34±0.22 mg/L and 0.37±0.22 mg/L in hepatitis B and hepatitis C patients respectively. Analysis of t-test showed there is no significant difference between 2 groups regarding to plasma zinc level (P = 0.745).
It is concluded that zinc level of studied cirrhotic patients is less than half of the normal range. Moreover, there is no difference in plasma zinc level between cirrhotic patients due to hepatitis B or hepatitis C. Regarding to this result, supplementation with complementary zinc, may be recommended in both groups in order to optimize the nutritional support and probably better the treatment response.
锌（Zn）在肝脏的生理功能中具有多种重要作用。此外，据报道锌的给药在病毒性肝炎的药物治疗中具有重要作用。先前的研究涵盖了血浆锌水平降低的肝硬化患者。由于伊朗人饮食中植酸盐含量高，评估伊朗肝硬化患者这一独特人群的锌水平似乎很有必要。关于病因、疾病进展和治疗，伊朗人群中两种最常见的肝硬化病因（乙型肝炎和丙型肝炎）存在一些差异，并且这两种病因导致的肝硬化患者的锌水平可能不同。本研究旨在阐明这一问题。
2008年4月至2008年11月期间，采用原子吸收法测定了塔利加尼医院（伊朗德黑兰一家胃肠和肝脏疾病转诊中心）60例因乙型或丙型肝炎接受治疗的肝硬化住院患者的血浆锌水平。
乙型肝炎和丙型肝炎患者的平均±标准差（SD）血浆锌水平分别为0.34±0.22mg/L和0.37±0.22mg/L。t检验分析表明，两组患者的血浆锌水平无显著差异（P = 0.745）。
得出的结论是，所研究的肝硬化患者的锌水平低于正常范围的一半。此外，乙型或丙型肝炎所致肝硬化患者的血浆锌水平无差异。基于这一结果，可能建议两组患者补充锌，以优化营养支持并可能改善治疗反应。
