Cesur Salih, Cebeci Sevsen Altinay, Kavas Guzin Ozelci, Aksaray Sebahat, Tezeren Deniz
Refik Saydam Hygiene Centre, Tuberculosis Reference and Research Laboratory, Ankara, Turkey.
J Infect. 2005 Jul;51(1):38-40. doi: 10.1016/j.jinf.2004.08.012.
The aim of this study was to measure the alterations in serum trace elements, including zinc and copper in patients with chronic hepatitis and to compare with the results of healthy individuals. The serum zinc and copper concentrations were measured by using atomic absorption spectrophotometer in sera of patients with chronic hepatitis and statistically compared with those of healthy individuals. One hundred and five subjects, 71 patients with chronic hepatitis B (46 asymptomatic carriers, 25 chronic active hepatitis B) and 34 healthy individuals were included in this study. Sera of patients with chronic hepatitis and statistically compared with those of healthy individuals. Serum zinc concentrations were 104+/-24.98 microg/dl in asymptomatic carriers, 97+/-16.03 microg/dl in chronic active hepatitis and 108+/-21.07 in healthy controls, respectively. Serum copper concentrations were 88+/-17.8 microg/dl in asymptomatic carriers, 86+/-20.02 microg/dl in patients with chronic active hepatitis B and 88+/-13.59 microg/dl in healthy controls, respectively. Serum zinc and copper concentrations were not statistically different in patients with chronic hepatitis B compared with those of healthy individuals (p>0.05). Serum trace element concentrations did not show statistical alterations in patients with chronic hepatitis B compared with healthy subjects.
本研究的目的是测定慢性肝炎患者血清中的微量元素变化，包括锌和铜，并与健康个体的结果进行比较。采用原子吸收分光光度计测定慢性肝炎患者血清中的锌和铜浓度，并与健康个体进行统计学比较。本研究纳入了105名受试者，其中71例慢性乙型肝炎患者（46例无症状携带者，25例慢性活动性乙型肝炎患者）和34名健康个体。对慢性肝炎患者的血清进行检测并与健康个体进行统计学比较。无症状携带者的血清锌浓度分别为104±24.98微克/分升，慢性活动性肝炎患者为97±16.03微克/分升，健康对照者为108±21.07微克/分升。无症状携带者的血清铜浓度分别为88±17.8微克/分升，慢性活动性乙型肝炎患者为86±20.02微克/分升，健康对照者为88±13.59微克/分升。慢性乙型肝炎患者的血清锌和铜浓度与健康个体相比无统计学差异（p>0.05）。与健康受试者相比，慢性乙型肝炎患者的血清微量元素浓度未显示出统计学变化。
