[丹皮酚-β-环糊精包合物结肠靶向给药片的制备]
[Preparation of paeonol-beta-cyclodextrin inclusion complex loaded colon specific delivery tablets].
作者信息
Wang Tongyan, Cui Qihua, Cao Qingri, Cui Jinghao
机构信息
Department of Pharmaceutics, College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2011 Nov;36(21):2956-9.
OBJECTIVE
To prepare paeonol-beta-cyclodextrin inclusion complex (Pae-beta-CYD) loaded colon-specific release tablets.
METHOD
The core tablets were prepared with the mixture of Pae-beta-CYD inclusion complex, peotin and calcium acetate, and coated with ethanolic solution of Eudragit S100. The effects of coating weight, amount of plasticizer, curing time and temperature on the release of drug from tablets were investigated in vitro.
RESULT
About 5-6 h retarded release of paeonol in the dissolution media of pectinase or rats colon contents were obtained by 12% coating weight gain and 20% Dibutyl phthalate (DBP) was used as plasticizer, and subsequently curing the tablets at 45 degrees C for 12 h.
CONCLUSION
Pae-beta-CYD loaded colon-specific release tablets showed pH environment and enzyme dependant release properties.
目的
制备载有丹皮酚-β-环糊精包合物（Pae-β-CYD）的结肠定位释放片。
方法
以Pae-β-CYD包合物、果胶和醋酸钙的混合物制备片芯，并用Eudragit S100乙醇溶液包衣。体外考察包衣增重、增塑剂用量、固化时间和温度对片剂药物释放的影响。
结果
包衣增重12%，使用20%邻苯二甲酸二丁酯（DBP）作为增塑剂，随后在45℃固化片剂12小时，在果胶酶或大鼠结肠内容物的溶出介质中丹皮酚可实现约5-6小时的缓释。
结论
载Pae-β-CYD的结肠定位释放片具有pH环境和酶依赖性释放特性。
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