黑质纹状体通路受损的猫脑内注射印防己毒素和卡巴胆碱的作用
The effects of intranigral injections of picrotoxin and carbachol in cats with a lesioned nigrostriatal pathway.
作者信息
Wolfarth S, Wand P, Sontag K H
出版信息
Neurosci Lett. 1979 Feb;11(2):197-200. doi: 10.1016/0304-3940(79)90127-7.
Picrotoxin, carbachol and atropine were injected intranigrally through chronically implanted crannulae in cats. The drug-induced behavioural syndromes, mainly asymmetric behaviour, were analyzed. The changes in these syndromes after 6-hydroxydopamine (6-OHDA) lesion of the substantia nigra (SN) indicate that, in addition to the dopaminergic (DA), a non-catecholaminergic (non-CA) nigral output exists, both being responsible for asymmetric behaviour. It is further suggested that gamma-aminobutyric acid (GABA) receptors are present on both dopaminergic and non-CA nigral output neurons, while acetylcholine (ACh) receptors, responsible for asymmetric behaviour, are almost exclusively located on non-CA nigral output neurons.
通过长期植入猫的颅骨套管向黑质内注射印防己毒素、卡巴胆碱和阿托品。分析了药物诱发的行为综合征，主要是不对称行为。黑质经6-羟基多巴胺（6-OHDA）损伤后这些综合征的变化表明，除多巴胺能（DA）外，还存在一种非儿茶酚胺能（非CA）黑质输出，两者均与不对称行为有关。进一步表明，多巴胺能和非CA黑质输出神经元上均存在γ-氨基丁酸（GABA）受体，而负责不对称行为的乙酰胆碱（ACh）受体几乎只位于非CA黑质输出神经元上。
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