[大鼠黑质单侧注射印防己毒素诱导的行为改变]
[Behavior modifications induced by unilateral administration of picrotoxin into rat substantia nigra].
作者信息
Boulu R, Lebas M, Ngoma-Yengo P
出版信息
C R Acad Hebd Seances Acad Sci D. 1977 Dec 19;285(16):1549-52.
PMID:417832
Abstract
Intranigral injection of picrotoxin in Rats induced contralateral rotation and stereotyped behaviour. These responses were significantly altered following neuroleptic treatment (haloperiod, pimozide) or ipsilateral striatal electrolytic destruction. The present results provide behavioural evidence for gamma-aminobutyric acid-mediated inhibition of the dopaminergic nigrostriatal pathway.
摘要
向大鼠黑质内注射印防己毒素可诱发对侧旋转和刻板行为。在接受抗精神病药物治疗（氟哌啶醇、匹莫齐特）或同侧纹状体电解毁损后，这些反应发生了显著改变。目前的结果为γ-氨基丁酸介导的对多巴胺能黑质纹状体通路的抑制作用提供了行为学证据。
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[Behavior modifications induced by unilateral administration of picrotoxin into rat substantia nigra].[大鼠黑质单侧注射印防己毒素诱导的行为改变]
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Neurosci Lett. 1979 May;12(2-3):323-8. doi: 10.1016/0304-3940(79)96083-x.
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