Brignardello Jerusa, Morales Pamela, Diaz Erik, Brunser Oscar, Gotteland Martin
Laboratory of Microbiology and Probiotics, Institute of Nutrition and Food Technology (INTA), Univ. of Chile, Santiago, Chile.
Arch Latinoam Nutr. 2011 Jun;61(2):149-53.
Obesity is associated with a low grade inflammation which contributes to the development of insulin resistance and diabetes. The aim of this study was to assess the total saturated (SFAs), monounsaturated (MUFAs) and polyunsaturated fatty acids (PUFAs) in plasma from asymptomatic obese subjects and to determine the arachidonic/eicosapentanoic acid ratio [ARA/EPA] as a marker of inflammation, and its eventual association with ultrasensitive CRP. Fourteen obese (34.4 +/- 11.1y.; BMI: 36.0 +/- 4,5 kg/m2) and 12 normal-weight (30.6 +/- 7.8y.; BMI: 23,6 +/- 2,4 kg/m2) subjects were recruited and their plasma fatty acids were determined by gas chromatography. usCRP was higher in the obese subjects (p = 0.01) and correlates with their body fat content. The percentages of SFAs, MUFAs, PUFAs were not affected in the obese subjects but their concentrations were increased, compared with the control group. However, no differences in the long chain PUFAs (DHA and EPA) concentrations or in the plasmatic ARA/EPA ratio were observed in these subjects. These observations do not support a relation between the ARA/EPA ratio and the presence of low grade inflammation evaluated by plasma usCRP in this group of asymptomatic obese subjects.
肥胖与低度炎症相关，这种炎症会促进胰岛素抵抗和糖尿病的发展。本研究的目的是评估无症状肥胖受试者血浆中的总饱和脂肪酸（SFAs）、单不饱和脂肪酸（MUFAs）和多不饱和脂肪酸（PUFAs），并确定花生四烯酸/二十碳五烯酸比值[ARA/EPA]作为炎症标志物，以及它与超敏CRP的最终关联。招募了14名肥胖者（34.4±11.1岁；BMI：36.0±4.5kg/m²）和12名正常体重者（30.6±7.8岁；BMI：23.6±2.4kg/m²），并通过气相色谱法测定他们的血浆脂肪酸。肥胖受试者的超敏CRP较高（p = 0.01），且与他们的体脂含量相关。与对照组相比，肥胖受试者中SFAs、MUFAs、PUFAs的百分比未受影响，但它们的浓度有所增加。然而，在这些受试者中未观察到长链PUFAs（DHA和EPA）浓度或血浆ARA/EPA比值的差异。这些观察结果不支持在这组无症状肥胖受试者中，ARA/EPA比值与通过血浆超敏CRP评估的低度炎症之间存在关联。
