Becopoulos T, Georgoulias D, Constantinides C, Stathakis H, Kosmidis J
Department of Urology, Athens University, Greece.
J Chemother. 1990 Aug;2(4):244-6. doi: 10.1080/1120009x.1990.11739024.
Six antimicrobial agents were administered to 48 patients (divided in 6 groups) who underwent prostatectomy. Half of the patients received the antibiotic in a single dose one hour before the operation and the rest in divided doses 24 hours before the operation. The concentration levels in serum and in prostatic tissue were measured for each of the antibiotics and for each mode of administration. The obtained ratios of prostatic tissue to serum concentrations and the relative antimicrobial activity to local pathogens of each agent indicate that the agent of choice for prostatic disease is netilmicin followed by aztreonam, cefuroxime and the ticarcillin-clavulanic acid combination.
对48例接受前列腺切除术的患者（分为6组）使用了六种抗菌药物。一半患者在手术前1小时接受单剂量抗生素，其余患者在手术前24小时接受分剂量抗生素。对每种抗生素和每种给药方式都测量了血清和前列腺组织中的浓度水平。所获得的前列腺组织与血清浓度的比率以及每种药物对局部病原体的相对抗菌活性表明，前列腺疾病的首选药物是奈替米星，其次是氨曲南、头孢呋辛和替卡西林 - 克拉维酸组合。
