Madsen P O, Dhruv R, Friedhoff L T
Antimicrob Agents Chemother. 1984 Jul;26(1):20-1. doi: 10.1128/AAC.26.1.20.
The concentrations of aztreonam in human prostatic tissue specimens obtained by transurethral resection were measured in nine patients after the intramuscular administration of a single 1-g dose. The average concentration of aztreonam was 7.8 microgram/g of prostate between 50 and 180 min after dosage. The average ratio of the drug concentration in prostate to that in serum was 0.25. The concentrations of aztreonam achieved were significantly higher than the MICs for most members of the family Enterobacteriaceae implicated in chronic prostatitis.
对9例患者单次肌内注射1g剂量氨曲南后，通过经尿道切除术获取的人前列腺组织标本中氨曲南的浓度进行了测定。给药后50至180分钟，氨曲南在前列腺中的平均浓度为7.8微克/克。前列腺中药物浓度与血清中药物浓度的平均比值为0.25。所测得的氨曲南浓度显著高于与慢性前列腺炎相关的大多数肠杆菌科成员的最低抑菌浓度。
