College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
J Pharm Pharmacol. 2012 Mar;64(3):326-36. doi: 10.1111/j.2042-7158.2011.01391.x. Epub 2011 Nov 10.
This review discusses the limitations and applications of the everted gut sac model in studying drug absorption, metabolism, and interaction.
The mechanism of drug absorption, interaction and the effect of factors such as age, sex, species, chronic therapy, and disease state on drug absorption have been summarized. The experimental conditions and their effects on the outcomes of trials have been discussed also.
The everted sac model is an efficient tool for studying in-vitro drug absorption mechanisms, intestinal metabolism of drugs, role of transporter in drug absorption, and for investigating the role of intestinal enzymes during drug transport through the intestine.
本综述讨论了外翻肠囊模型在研究药物吸收、代谢和相互作用方面的局限性和应用。
总结了药物吸收的机制、相互作用以及年龄、性别、物种、慢性治疗和疾病状态等因素对药物吸收的影响。还讨论了实验条件及其对试验结果的影响。
外翻肠囊模型是研究药物吸收机制、药物在肠道内的代谢、转运体在药物吸收中的作用以及肠内酶在药物通过肠道转运过程中的作用的有效工具。
