Artursson P
Department of Pharmaceutics, Uppsala University, Sweden.
Crit Rev Ther Drug Carrier Syst. 1991;8(4):305-30.
This review deals with cell culture models for studies of drug absorption across the intestinal mucosa. The selection of appropriate cells and cell culture conditions is discussed, guidelines for the characterization of the cell models are presented, and the intestinal barriers to drug absorption are discussed and compared with those in the cell culture models. Finally, recent applications of the cell culture models in drug and peptide absorption and metabolism studies are reviewed.
本综述涉及用于研究药物跨肠黏膜吸收的细胞培养模型。讨论了合适细胞和细胞培养条件的选择，给出了细胞模型表征的指导原则，并讨论了药物吸收的肠道屏障并与细胞培养模型中的屏障进行了比较。最后，综述了细胞培养模型在药物和肽吸收及代谢研究中的最新应用。
