Division of Immunogenetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Exp Cell Res. 2012 Jul 1;318(11):1324-31. doi: 10.1016/j.yexcr.2012.01.019. Epub 2012 Jan 28.
c-FLIP proteins (isoforms: c-FLIP(L), c-FLIP(S), and c-FLIP(R)) play an essential role in the regulation of death receptor (DR)-induced apoptosis and NF-κB activation. Here, we discuss multiple mechanisms by which c-FLIPs control NF-κB activation and the life/death decision made in cancer and immune cells. We focus on the role of c-FLIP in cellular signaling. We concentrate on c-FLIP protein modifications as well as on the regulation of c-FLIP expression levels. Furthermore, we discuss in detail how the exact quantity and dynamics of different c-FLIP isoforms in the cell influence the induction of pro- versus anti-apoptotic pathways.
c-FLIP 蛋白（异构体：c-FLIP(L)、c-FLIP(S) 和 c-FLIP(R)）在调节死亡受体（DR）诱导的细胞凋亡和 NF-κB 激活中起着至关重要的作用。在这里，我们讨论了 c-FLIP 控制 NF-κB 激活和决定癌症及免疫细胞生死的多种机制。我们专注于 c-FLIP 在细胞信号中的作用。我们集中讨论 c-FLIP 蛋白的修饰以及 c-FLIP 表达水平的调节。此外，我们详细讨论了细胞中不同 c-FLIP 异构体的数量和动态如何影响促凋亡和抗凋亡途径的诱导。
